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These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER MSDS Ref. It is also used in plaque assays for counting. Molecular weight: Not Applicable 1.5. SCMm_>x^O9l (n. << Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. << IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. 6 0 obj )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? BIOACCUMULATIVE POTENTIAL Microcrystalline Cellulose Side Effects. Find answers in our support articles. ( Microcrystalline Cellulose. /Type/Page Product Name: Microcrystalline Cellulose E460 1.2. 1. >> Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Packaging: 34 x 50 kgs fiber drums. } !1AQa"q2#BR$3br Manufacturer: FMC BioPolymer. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. The table below shows the most common physicochemical parameters of this raw material. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Remove The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. endobj This Microcrystalline Cellulose . Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. gac74 [#B6`Wnw7 More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. >> (&E. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). ( Meet our leadership team. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. CAS #: 9004-34-6 1.6. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. No. 130. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. endobj The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) P}MFbN#[>r(y A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Product and Company Identification . Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Superior Performance: Provides excellent water uptake and rapid swelling . Revision No. q9;v80q>jZ Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. 2 0 obj Avicel PC 611 Microcrystalline Cellulose. %PDF-1.4 Are you sure you want to delete your template? % They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Your file is uploaded and ready to be published. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& 1 0 obj There have always been two different points of view for the liquidity of MCC. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . % . MATERIAL SAFETY DATA SHEET. Safety Data Sheet (SDS) Viewer. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Explore how you can develop your career and bring your creative ideas to life at IFF. HMo@9, U Q!R/1*;` Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? xv}O2' H~KEe9>G/,:9\i !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Regulatory Information Delivering efficient and robust formulations. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The data shown below apply only to Avicel PH 101. Production of Pharmaceutical Grade Microcrystalline Cellulose. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM SUBSTANCE IDENTIFICATION 1.1. Medium size standard MCC grade, suited for the majority of directly compressible actives. The short-term limit for total inhalable dust is 20 mg/m3. There may be more fiber in your food than you realized. The aqueous solution to barrier membrane coating. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Origin(s): Plant/Botanical. Avicel RC-591 & CL-611 - Description. Fiber supplements can lessen the absorption of some . Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . (1962). << %PDF-1.4 The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. : 9004-34-6 Date Approved: 01/31/2008 . FMC Corporation. Truly distinctive drug delivery solutions. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. endobj "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Protect them from sunshine or rain. Learn about FMC's industry leading goal of net-zero emissions by 2035. Avicel Microcrystalline Cellulose: Chemical Identifiers. Instead, they obtained a stable colloidal suspension. endobj Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. : 160182 Date Approved: 05/25/2010 Revision No. : 1. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Microcrystalline Cellulose / Avicel PH-102. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. No. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Gloves, eye protection and a dust mask should be used. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. High performance lubricant that brings more to the tablet. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. 9,LL!z The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. B;vLZpHU%ChUyD+[ Watch Now. CAS #: 9004-34-6 MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Micro Crystalline Cellulose. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Hi, let us know if you have any questions as you visit our website. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Revision No. Apply today! >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Microcrystalline Cellulose / Avicel PH-102. No. Avicel PH-200 microcrystalline cellulose NF, Ph. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. CAS 9004-34-6. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). <> "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC 4 0 obj The most. pH 6.0 to 8.0 . Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. MATERIAL SAFETY DATA SHEET. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Molecular weight: Not Applicable 1.5. 51395-75-6 Avicel RC 591. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b gwf;J(e0o|1p{R~P^);ao!%{0KD7. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Thus, Avicel contributes no or very few calories to the food system. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. We are artists at heart and creators by nature. ChemicalBook. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Powder becomes slippery when wet. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . 0.25 - 0.37. X\o^ Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine }o]X4]. MCC helps in the formation of spheres because of its . Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Battista, O. Performing this action will revert the following features to their default settings: Hooray! Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Cellulose microcrystalline for column chromatography. . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. 2021 Annual Report. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. A., and Smith, P. A. %PDF-1.5 Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. JFIF ` ` ZExif MM * J Q Q Q C Alginates also function as actives in some anti-reflux products. stream pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Go to Investor Relations. EMCOCEL XLM 90. Created Date: 2/10/2020 8:51:41 PM . Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Request media, explore upcoming events and read our latest updates. ( It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Manufactured by: China . Have an order or account question, find answers in our Online Support articles. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. It . They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Safety Data Sheet for Cellulose microcrystalline 102331. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. 6 ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. /MediaBox [0 0 612 792] bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Millipore. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Avicel PH-101. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Chemical Formula: (C6H10O5)n 1.4. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. The typical mean particle size is 20200 m. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. No. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . MATERIAL SAFETY DATA SHEET Version: 1.0 1. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. EINECS #: 232-674-9 1.7. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. >> This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions.

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